In Protect and Defend, the action begins in the heart of Iran, where billions of dollars are being spent on the development of a nuclear program. No longer willing to wait for the international community to stop its neighboring enemy, Israel launches one of the most creative and daring espionage operations ever conceived. The attack leaves a radioactive tomb and environmental disaster in the middle of Iran's second largest city. An outraged Iranian government publicly blames both Israel and the United States for the attack and demands retribution. Privately, Iran's bombastic president wants much more. He wants America and Israel to pay for their aggression with blood.

Enter Mitch Rapp, America's top counterterrorism operative. Used to employing deception, Rapp sees an opportunity where others see only Iranian reprisals that could leave thousands of Americans dead. Rapp convinces President Josh Alexander to sign off on a risky operation that will further embarrass the Iranian government and push their country to the brink of revolution. As part of the plan, CIA director Irene Kennedy is dispatched to the region for a clandestine meeting with Azad Ashani, her Iranian counterpart.